Bisphenol A: there is no more in the plastic but it is not better

Since the controversy over the risks of exposure to Bisphenol A (endocrine disruptor), contained in plastics, manufacturers have sought substitutes. They found one in particular, bisphenol S (BPS), but it turns out not to be without effects on health and in particular to encourage the formation of fat cells.

Plastics “without bisphenol” A (BPA) have become a reassuring argument, since they highlight the elimination of this much maligned endocrine disruptor. But these “BPA-free” plastics may instead contain bisphenol S (BPS) which, despite having a significantly different chemical structure than BPA, could pose similar health concerns, according to this new study published in Endocrinology, the journal of the Endocrine Society.

Different concentrations tested on human cells

A Canadian research team has created a model of human cells to test the effects of exposure to BPS. They used pre-adipocytes, taken from female volunteers at the hips, waist and abdomen. They tested exposure to different concentrations of BPS. They found that the higher concentration, like the lower, produced greater accumulation of lipids in the cells.

Bisphenol A or not: weight gain is here

Lead author Ella Atlas of Health Canada says the study is the first to show that exposure to BPS, even at very low doses, can induce the formation of fat cells in humans. And to continue that this suggests that BPS and BPA have similar effects on fat cells, lipid accumulation and the expression of genes important for lipid metabolism.


Boucher JG et al Bisphenol S Induces Adipogenesis in Primary Human Preadipocytes From Female Donors Endocrinology.doi.org/10.1210/en.2015-1872

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