“French Paradox”: resveratrol in wine protects memory

Resveratrol, a compound particularly abundant in red grapes (and peanuts), may help slow age-related memory decline, according to a Texas study published in the journal Scientific Reports.

Resveratrol is a polyphenol of the stilbene class present in the skin of certain fruits such as grapes (especially red ones), blackberries, blueberries and other berries or even, more curiously, peanuts. It is also found in significant quantities in red wine where its presence has often been invoked to explain the beneficial health effects of moderate consumption of red wine…especially in the “French paradox”.

Resveratrol has effects on the hippocampus

For the Texan researchers, resveratrol would also have positive effects on the hippocampus, a region of the brain critical for memory or learning. However, these capacities tend to regress with aging.

In their randomized controlled study, conducted on old rodents, the scientists observed significant results on both learning and memory, as well as the mood of the animals. Thus, in animals not receiving the polyphenol, spatial memory had significantly declined between 22 and 25 months, whereas it improved markedly in the group of rats on resveratrol, as did learning.

Twice as many neurons with resveratrol.. in mice

Analysis of brain tissue reveals neurogenesis (the growth and development of neurons) nearly doubled with resveratrol. Cerebral microvasculature was also improved and resveratrol also reduced chronic hippocampal inflammation.

The authors are now examining the molecular mechanisms associated with this brain protection and plan to study the impact of lower doses of resveratrol (closer to human dietary intake) over the long term, to find out if the benefits are retained on the brain. age.

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Maheedhar Kodali: Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature, and Reduced Glial Activation. Scientific Reports


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