FAQ

Vitamin D: reduce the risk of colorectal cancer by 50%

New findings suggest that around 300 IU of vitamin D daily may be correlated with a 50% reduction in the risk of colorectal cancer in young adults.

Changes in lifestyle and dietary habits may be partly responsible for the increasing incidence of colorectal cancer in young adults. Scientists have speculated that the decline in average dietary vitamin D intake since the 1980s may be a factor in this increased incidence. One study linked a higher total vitamin D intake to a lower risk of colorectal cancer in adults under 50. The results suggest that encouraging people in this age group to increase their vitamin D intake could be a cheap, low-risk adjunct to screening for the disease.

Colorectal cancer (cancer of the colon or rectum) is very common. While the overall incidence of colorectal cancer has declined over the past two decades, the number of young adults with the disease has increased. If current trends continue, researchers estimate that by 2030, nearly 11% of colon cancers and 23% of rectal cancers will occur in adults under the age of 50. About half of people with early-onset colorectal cancer have no family history of the disease or known genetic risk factors, so changing lifestyles and eating habits may play a role. role in increasing its incidence. Researchers have previously linked early-onset colorectal cancer to obesity and sedentary lifestyles.

They also looked at dietary changes as another possible culprit for the increased numbers. Researchers suggest that reduced consumption of vitamin D-rich foods, such as fish, mushrooms and eggs, is a prime suspect. Several studies have shown that vitamin D protects against colorectal cancer in general, but none have focused on the early form of the disease. Dietary changes over the past decades are one of many potential risk factors studied in relation to early-onset colorectal cancer. We know that diet and lifestyle are strongly linked to colorectal cancer as a whole (regardless of age of diagnosis), so it makes sense to look at whether some of the risk factors that have changed recently, like vitamin D, may contribute to the increase in the number of early-onset colorectal cancers.

Vitamin D from food and dietary supplements

The researchers analyzed data on the diet, lifestyle and medical history of 116,429 nurses between the ages of 25 and 42. The nurses participated in the Nurses’ Health Study II (NHS II) which began in 1989. In this prospective study, participants complete questionnaires every two years about their lifestyle, medical history and other information related to health. They also answer more detailed questions about their diet in a food frequency questionnaire every 4 years. The researchers used this data to estimate the volunteers’ total vitamin D intake from their diet and dietary supplements.

Between 1991 and 2015, 111 new cases of early-onset colorectal cancer were diagnosed among participants. After adjusting for other known risks, such as smoking, alcohol consumption, red meat consumption and sedentary behaviors, they found that total vitamin D intake was significantly associated with a reduced risk of colorectal cancer at early start. The protective effect seemed to be greater for vitamin D from dietary sources than for that from supplements. Scientists have also found an association between low vitamin D intake and disease precursors, known as adenomas and polyps.

The results suggest that as little as 300 [unités internationales ou UI par jour] of vitamin D may be associated with a 50% reduction in the risk of early-onset colorectal cancer. The results are published in the journal Gastroenterology.

Prioritize vitamin D from food sources

The authors conclude that, if confirmed, their findings could lead to recommendations for higher vitamin D intake as an inexpensive, low-risk adjunct to colorectal cancer screening to prevent the disease in adults from under 50 years old. The fact that dietary vitamin D appears to have a stronger protective effect than vitamin D from supplements could be due to chance. Another possible explanation could be that certain nutrients in multivitamins could counterbalance the beneficial effects of vitamin D. There could also be additional factors in the diet, such as calcium, that could work with vitamin D to reduce the risk

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Early-onset colorectal cancer accounts for more than 10% of all colorectal cancer cases and this incidence is increasing. Observational studies like this shed some light on the role of diet and specific factors like vitamin D in increasing the incidence of [cancer colorectal] early onset, but more research is needed to draw conclusions.

Sources

Trends in vitamin D intake from food sources among adults in the Minneapolis St Paul, MN Metropolitan area, 1980–82 through 2007–2009

Total Vitamin D Intake and Risks of Early-Onset Colorectal Cancer and Precursors

* The information and services available on pressesante.com in no way replace the consultation of competent health professionals. [HighProtein-Foods.com]

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